解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Identifying the genomic basis underlying local adaptation is paramount to evolutionary biology, and bears many applications in the fields of conservation biology, crop, and animal breeding, as well as personalized medicine. Although many approaches have been developed to detect signatures of positive selection within ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy053
更新日期:2018-06-01 00:00:00
abstract::Detecting selection on codon usage (CU) is a difficult task, since CU can be shaped by both the mutational process and selective constraints operating at the DNA, RNA, and protein levels. Yang and Nielsen (2008) developed a test (which we call CUYN) for detecting selection on CU using two competing mutation-selection ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy047
更新日期:2018-06-01 00:00:00
abstract::High-affinity antibodies arise within weeks of infection from the evolution of B-cell receptors under selection to improve antigen recognition. This rapid adaptation is enabled by the distribution of highly mutable "hotspot" motifs in B-cell receptor genes. High mutability in antigen-binding regions (complementarity d...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy024
更新日期:2018-05-01 00:00:00
abstract::MicroRNA (miRNA) sponges are vital components of posttranscriptional gene regulation. Yet, only a limited number of miRNA sponges have been identified. Here, we show that the recently evolved noncoding tumor suppressor transcript, antisense RNA to TP73 gene (TP73-AS1), functions as a natural sponge of human-specific m...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy022
更新日期:2018-05-01 00:00:00
abstract::Selection on codon usage bias is well documented in a number of microorganisms. Whether codon usage is also generally shaped by natural selection in large organisms, despite their relatively small effective population size (Ne), is unclear. In animals, the population genetics of codon usage bias has only been studied ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy015
更新日期:2018-05-01 00:00:00
abstract::Most phylogenetic models assume that the evolutionary process is stationary and reversible. In addition to being biologically improbable, these assumptions also impair inference by generating models under which the likelihood does not depend on the position of the root. Consequently, the root of the tree cannot be inf...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx294
更新日期:2018-04-01 00:00:00
abstract::Although any genotype-phenotype relationships are a result of evolution, little is known about how natural selection and neutral drift, two distinct driving forces of evolution, operate to shape the relationships. By analyzing ∼500 yeast quantitative traits, we reveal a basic "supervisor-worker" gene architecture unde...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx288
更新日期:2018-03-01 00:00:00
abstract::The distribution of fitness effects of mutations is a factor of fundamental importance in evolutionary biology. We determined the distribution of fitness effects of 510 mutants that each carried between 1 and 10 mutations (synonymous and nonsynonymous) in the hisA gene, encoding an essential enzyme in the l-histidine ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx325
更新日期:2018-03-01 00:00:00
abstract::Reticulate species evolution, such as hybridization or introgression, is relatively common in nature. In the presence of reticulation, species relationships can be captured by a rooted phylogenetic network, and orthologous gene evolution can be modeled as bifurcating gene trees embedded in the species network. We pres...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx307
更新日期:2018-02-01 00:00:00
abstract::Lineage-specific gene duplications contribute to a large variation in specialized metabolites among different plant species. There is also considerable variability in the specialized metabolites within a single plant species. However, it is unclear whether copy number variations (CNVs) derived from gene duplication ev...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx234
更新日期:2017-12-01 00:00:00
abstract::Signaling peptides enable communication between cells, both within and between individuals, and are therefore key to the control of complex physiological and behavioral responses. Since their small sizes prevent direct transmission to secretory pathways, these peptides are often produced as part of a larger polyprotei...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx243
更新日期:2017-12-01 00:00:00
abstract::Siberia is one of the coldest environments on Earth and has great seasonal temperature variation. Long-term settlement in northern Siberia undoubtedly required biological adaptation to severe cold stress, dramatic variation in photoperiod, and limited food resources. In addition, recent archeological studies show that...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx226
更新日期:2017-11-01 00:00:00
abstract::Modifications to transcriptional regulators play a major role in adaptation. Here, we compared the effects of multiple beneficial mutations within and between Escherichia coli rpoB, the gene encoding the RNA polymerase β subunit, and rho, which encodes a transcriptional terminator. These two genes have harbored adapti...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx216
更新日期:2017-11-01 00:00:00
abstract::Isoprene is the most abundant biogenic volatile hydrocarbon compound naturally emitted by plants and plays a major role in atmospheric chemistry. It has been proposed that isoprene synthases (IspS) may readily evolve from other terpene synthases, but this hypothesis has not been experimentally investigated. We isolate...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx178
更新日期:2017-10-01 00:00:00
abstract::Polyploidization events have occurred during the evolution of many fungi, plant, and animal species and are thought to contribute to speciation and tumorigenesis, however little is known about how ploidy level contributes to adaptation at the molecular level. Here we integrate whole genome sequencing, RNA expression a...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx205
更新日期:2017-10-01 00:00:00
abstract::When bacteria evolve resistance against a particular antibiotic, they may simultaneously gain increased sensitivity against a second one. Such collateral sensitivity may be exploited to develop novel, sustainable antibiotic treatment strategies aimed at containing the current, dramatic spread of drug resistance. To da...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx158
更新日期:2017-09-01 00:00:00
abstract::Plants can show long-term effects of environmental stresses and in some cases a stress "memory" has been reported to persist across generations, potentially mediated by epigenetic mechanisms. However, few documented cases exist of transgenerational effects that persist for multiple generations and it remains unclear i...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx150
更新日期:2017-08-01 00:00:00
abstract::Random genetic drift, or stochastic change in gene frequency, is a fundamental evolutionary force that is usually defined within the ideal Wright-Fisher (WF) population. However, as the theory is increasingly applied to populations that deviate strongly from the ideal model, a paradox of random drift has emerged. When...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx161
更新日期:2017-08-01 00:00:00
abstract::Several authors reported lower frequencies of protein sequence convergence between more distantly related evolutionary lineages and attributed this trend to epistasis, which renders the acceptable amino acids at a site more different and convergence less likely in more divergent lineages. A recent primate study, howev...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx109
更新日期:2017-07-01 00:00:00
abstract::Hybridization is often considered maladaptive, but sometimes hybrids can invade new ecological niches and adapt to novel or stressful environments better than their parents. The genomic changes that occur following hybridization that facilitate genome resolution and/or adaptation are not well understood. Here, we exam...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx098
更新日期:2017-07-01 00:00:00
abstract::TYRO3, AXL, and MERTK (TAM) receptors are a family of receptor tyrosine kinases that maintain homeostasis through the clearance of apoptotic cells, and when defective, contribute to chronic inflammatory and autoimmune diseases such as atherosclerosis, multiple sclerosis, systemic lupus erythematosus, rheumatoid arthri...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx102
更新日期:2017-07-01 00:00:00
abstract::Mitochondrial genomes of metazoans, given their elevated rates of evolution, have served as pivotal markers for phylogeographic studies and recent phylogenetic events. In order to determine the dynamics of spontaneous mitochondrial mutations in small populations in the absence and presence of selection, we evolved mut...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx051
更新日期:2017-06-01 00:00:00
abstract::The genomes are folded in a complex three-dimensional (3D) structure. Some features of this organization are common for all eukaryotes, but little is known about its evolution. Here, we have studied the 3D organization and regulation of zebrafish globin gene domain and compared its organization and regulation with tho...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx100
更新日期:2017-06-01 00:00:00
abstract::Transcriptional control of gene expression is regulated by biochemical interactions between cis-regulatory DNA sequences and trans-acting factors that form complex regulatory networks. Genetic changes affecting both cis- and trans-acting sequences in these networks have been shown to alter patterns of gene expression ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx068
更新日期:2017-06-01 00:00:00
abstract::We present a new Bayesian method for estimating demographic and phylogenetic history using population genomic data. Several key innovations are introduced that allow the study of diverse models within an Isolation-with-Migration framework. The new method implements a 2-step analysis, with an initial Markov chain Monte...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx070
更新日期:2017-06-01 00:00:00
abstract::Wolbachia bacteria infect about half of all arthropods, with diverse and extreme consequences ranging from sex-ratio distortion and mating incompatibilities to protection against viruses. These phenotypic effects, combined with efficient vertical transmission from mothers to offspring, satisfactorily explain the invas...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx073
更新日期:2017-05-01 00:00:00
abstract::Focal copy number gains or losses are important genomic hallmarks of cancer. The genomic distribution of oncogenes and tumor-suppressor genes (TSG) in relation to focal copy number aberrations is unclear. Our analysis revealed that the mean distance of TSGs from oncogenes was significantly shorter than that of noncanc...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msw295
更新日期:2017-04-01 00:00:00
abstract::A major topic of interest in human prehistory is how the large-scale genetic structure of modern populations outside of Africa was established. Demographic models have been developed that capture the relationships among small numbers of populations or within particular geographical regions, but constructing a phylogen...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msw293
更新日期:2017-04-01 00:00:00
abstract::Deciphering invasion routes from molecular data is crucial to understanding biological invasions, including identifying bottlenecks in population size and admixture among distinct populations. Here, we unravel the invasion routes of the invasive pest Drosophila suzukii using a multi-locus microsatellite dataset (25 lo...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx050
更新日期:2017-04-01 00:00:00
abstract::Despite its population, geographic size, and emerging economic importance, disproportionately little genome-scale research exists into genetic factors that predispose Brazilians to disease, or the population genetics of risk. After identification of suitable proxy populations and careful analysis of tri-continental ad...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msw249
更新日期:2017-03-01 00:00:00
abstract::A recent study conducted the first genome-wide scan for selection in Inuit from Greenland using single nucleotide polymorphism chip data. Here, we report that selection in the region with the second most extreme signal of positive selection in Greenlandic Inuit favored a deeply divergent haplotype that is closely rela...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msw283
更新日期:2017-03-01 00:00:00
abstract::Dinoflagellates are algae of tremendous importance to ecosystems and to public health. The cell biology and genome organization of dinoflagellate species is highly unusual. For example, the plastid genomes of peridinin-containing dinoflagellates encode only a minimal number of genes arranged on small elements termed "...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msw235
更新日期:2017-02-01 00:00:00
abstract::Bivalves have evolved a range of complex shell forming mechanisms that are reflected by their incredible diversity in shell mineralogy and microstructures. A suite of proteins exported to the shell matrix space plays a significant role in controlling these features, in addition to underpinning some of the physical pro...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msw219
更新日期:2017-01-01 00:00:00
abstract::Multiple kelch13 alleles conferring artemisinin resistance (ART-R) are currently spreading through Southeast Asian malaria parasite populations, providing a unique opportunity to observe an ongoing soft selective sweep, investigate why resistance alleles have evolved multiple times and determine fundamental population...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msw228
更新日期:2017-01-01 00:00:00
abstract::The mammalian family Talpidae (moles, shrew moles, desmans) is characterized by diverse ecomorphologies associated with terrestrial, semi-aquatic, semi-fossorial, fossorial, and aquatic-fossorial lifestyles. Prominent specializations involved with these different lifestyles, and the transitions between them, pose outs...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msw221
更新日期:2017-01-01 00:00:00
abstract::Phenotypic convergence is an exciting outcome of adaptive evolution, occurring when different species find similar solutions to the same problem. Unraveling the molecular basis of convergence provides a way to link genotype to adaptive phenotypes, but can also shed light on the extent to which molecular evolution is r...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msw197
更新日期:2016-12-01 00:00:00
abstract::As the largest European herbivore, the wisent (Bison bonasus) is emblematic of the continent wildlife but has unclear origins. Here, we infer its demographic and adaptive histories from two individual whole-genome sequences via a detailed comparative analysis with bovine genomes. We estimate that the wisent and bovine...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msw144
更新日期:2016-11-01 00:00:00
abstract::Accelerated evolution of regulatory sequence can alter the expression pattern of target genes, and cause phenotypic changes. In this study, we used DNase I hypersensitive sites (DHSs) to annotate putative regulatory sequences in the human genome, and conducted a genome-wide analysis of the effects of accelerated evolu...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msw128
更新日期:2016-10-01 00:00:00
abstract::Endogenous retroviruses are genomic elements formed by germline infiltration by originally exogenous viruses. These molecular fossils provide valuable information about the evolution of the retroviral family. Lentiviruses are an extensively studied genus of retroviruses infecting a broad range of mammals. Despite a we...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msw149
更新日期:2016-10-01 00:00:00
abstract::Ever since Luria and Delbruck, the notion that mutation is random with respect to fitness has been foundational to modern biology. However, various studies have claimed striking exceptions to this rule. One influential case involves toxin-encoding genes in snails of the genus Conus, termed conotoxins, a large gene fam...
journal_title:Molecular biology and evolution
pub_type: 信件
doi:10.1093/molbev/msw140
更新日期:2016-10-01 00:00:00